Anti Glucagon-like peptide-1 (GLP-1 (1-36) amide)
Mouse monoclonal antibody
Cat.No. HYB 011-05
Preparation: Protein-A/G purified
Content: Available in 200 µL and 1 mL
Concentration: 1 mg/mL
Solvent: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
Storage: In the dark at 4-8ºC
GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. GLP-1 (1-36) amide is an incompletely prosessed precursor form showing relatively little bioactivity.
Synthetic peptide coupled to diphtheria toxoid with glutaraldehyde
HYB 011-05 is specific for the N-terminal region (residues 1-6) of the GLP-1. No crossreactitvity with GLP-1 (7-36) amide or (7-37). GLP-1 is 100% conserved in all tested mammalian species.
Residues 1-6 of GLP-1
HYB 011-05 reacts with the low activity enzyme GLP-1(1-36)amide, but not with either of the activated forms GLP-1(7-36)amide and GLP-1(7-37)amide.
| Method | Usability | Dilution guideline | References |
| ELISA | Yes | 1:40,000 | 1 |
| Immunoblotting | Not determined | ||
| Immunohistochemistry | Not determined |
1. Ghiglione M, Uttenthal LO, Koch C (1993) Monoclonal antibodies to glucagon-like peptide-1. Digestion 54:396-397.
Larger Picture (51kB)
The epitopes of 5 different monoclonal antibodies against GLP-1 (1-36) amide are shown in the above scheme
Downloads
HYB 011-05.pdf (11.82 kB) Product specification
GLP-1 Flyer.pdf (487.77 kB)
GLP-1 and Exendin brochure.pdf (442.02 kB) GLP-1 brochure
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